The skeletal musculature is important for ordinary engine capacities like strolling or relaxing. It represents somewhere in the range of 35 and 45% of complete body weight in people and is the most enthusiastically requesting tissue in the body. Skeletal muscle is a one of a kind tissue with multifaceted hierarchical game plan, requiring exact guideline of intracellular particles and collaboration by a huge number of cell proteins. Thus, it additionally has susceptibilities to a different cluster of poisonous affronts. Disturbances of skeletal muscle capacity can cause loss of development, multiorgan association and surprisingly organismal downfall. Notwithstanding immediate consequences for skeletal muscle, this tissue can likewise be liable for harm to far off tissues and organs by arrival of enormous intracellular proteins into the vasculature. As a particular subject, skeletal muscle toxicology has been generally missing from most of course books. Be that as it may, it addresses a significant and explicit objective of an assortment of normal and manufactured poisons. Here we present an outline of skeletal muscle physiology, including tissue engineering, vivacious substrate inclinations, and capacity. Lab techniques and symptomatic perceptions to be utilized for examining skeletal muscle injury in an examination and clinical setting are additionally talked about. At long last, we give an inside and out blueprint of skeletal muscle poisons masterminded by their proposed component of activity. The skeletal musculature is essential for ordinary engine capacities like strolling or relaxing. It represents somewhere in the range of 35 and 45% of complete body weight in people and is the most enthusiastically requesting tissue in the body. Skeletal muscle is a one of a kind tissue with unpredictable hierarchical game plan, requiring exact guideline of intracellular particles and participation by a large number of cell proteins. Thus, it likewise has susceptibilities to a different exhibit of harmful abuses. Confusions of skeletal muscle capacity can cause loss of development, multiorgan association and surprisingly organismal death. Notwithstanding immediate consequences for skeletal muscle, this tissue can likewise be answerable for harm to far off tissues and organs by arrival of huge intracellular proteins into the vasculature. As a particular point, skeletal muscle toxicology has been to a great extent missing from most of course readings. In any case, it addresses a significant and explicit objective of an assortment of regular and engineered poisons. Here we present an outline of skeletal muscle physiology, including tissue engineering, lively substrate inclinations, and capacity. Lab techniques and indicative perceptions to be utilized for examining skeletal muscle injury in an examination and clinical setting are likewise talked about. At last, we give a top to bottom framework of skeletal muscle poisons orchestrated by their proposed system of activity.